The dosage of a drug which is TOXIC in 50% of the population
The dosage of a drug which is LETHAL in 50% of the population
The range of drug plasma concentrations for which it is effective without causing toxic effects
When the body becomes less responsive to the effects of the drug, LARGER AND LARGER DOSES are needed for the same effect
Where a user develops a physical dependence on a drug
The negative effects of the administration of a drugs
Drug Receptor Interactions
- Agonistic: Drug acts in a similar way to substrate, activating the receptor and the associated response
- Antagonistic: Drug blocks the substrate binding site and prevents the natural substrate from activating the receptor
- Allosteric: Drug binds to a site other than the substrate binding site. This may increase/decrease the receptors response to the natural substrate
A drug which works by intercepting the pain stimulus at the SOURCE, it does this by preventing the synthesis of substances that cause pain.
A drug that work by temporarily bonding to opioid receptors in the BRAIN and present transmission of pain impulses
Patient's willingness and ability to take a medication in the correct doses, at the correct times for the whole course prescribed
Naturally occuring narcotic compounds from opium poppy (Morphine)
Any compound with a similar structure to morphine (Codeine, Heroin)
Opiates and Opioids must cross the Brain Blood Barrier to work, the more hydrophobic (non-polar) a compound is, the more rapidly it penetrates the BBB.
Waste which gives off small amounts of ionising radiation for short periods of time, these isotopes will have short half-lives and few nuclei decay each second
An optically active substance that is temporarily encorparated into an organic synthesis so that is can be carried out asymmetrically with the formation of a single enantiomer
This is the end of this topic.