IBDP Biology - Skeletal Muscle

In the IBDP Biology topic, you will learn about skeletal muscle.

1. Skeletal muscle is the tissue most commonly thought of

• Skeletal muscles cover your skeleton, giving your body its shape.
• Attached to your skeleton by tendons or directly to bone
• Under voluntary control (you consciously control what they do)

2. All body movement is caused by skeletal muscle contraction

• Skeletal muscles function almost continuously to maintain your posture, making one tiny adjustment after another to keep your body upright.

3.Important for holding your bones in the correct position

• Prevents your joints from dislocating
• Some skeletal muscles in your face are directly attached to your skin and contraction of one of these muscles changes your facial expression

4. Generates heat as a by-product of muscle activity

• This heat is vital for maintaining your normal body temperature

• At a very basic level each muscle fibre is made up of smaller fibres called myofibrils
• These contain even smaller structures called actin and myosin filaments. These filaments slide in and out between each other to form a muscle contraction, hence called the sliding filament theory

The diagram above shows part a myofibril called a sarcomere. This is the smallest unit of skeletal muscle that can contract. Sarcomeres repeat themselves over and over along the length of the myofibril.

Structures involved:

1. Myofibril: A cylindrical organelle running the length of the muscle fibre, containing Actin and Myosin filaments.
2. Sarcomere: The functional unit of the Myofibril, divided into I, A and H bands.
3. Actin: A thin, contractile protein filament, containing 'active' or 'binding' sites.
4. Myosin: A thick, contractile protein filament, with protrusions known as Myosin Heads.

• A series of events has to occur for muscle contraction to occur
• Described here is more detail than you require, but it good to get an appreciation of the scale of this process

1. A nervous impulse arrives at the neuromuscular junction, which causes a release of a chemical called Acetylcholine. The presence of Acetylcholine causes the depolarisation of the motor end plate which travels throughout the muscle by the transverse tubules, causing Calcium (Ca2+) to be released from the sarcoplasmic reticulum.

2. In the presence of high concentrations of Ca+, the Ca+ binds to Troponin, changing its shape and so moving Tropomyosin from the active site of the Actin. The Myosin filaments can now attach to the Actin, forming a cross-bridge.

3. The breakdown of ATP releases energy which enables the Myosin to pull the Actin filaments inwards and so shortening the muscle. This occurs along the entire length of every myofibril in the muscle cell.

4. The Myosin detaches from the Actin and the cross-bridge is broken when an ATP molecule binds to the Myosin head. When the ATP is then broken down the Myosin head can again attach to an Actin binding site further along the Actin filament and repeat the 'power stroke'. This repeated pulling of the Actin over the myosin is often known as the ratchet mechanism.

5. This process of muscular contraction can last for as long as there is adequate ATP and Ca2+ stores. Once the impulse stops the Ca2+ is pumped back to the Sarcoplasmic Reticulum and the Actin returns to its resting position causing the muscle to lengthen and relax.

1.The influx of calcium from the sarcoplasmic reticulum triggers the exposure of binding sites on action

2.Myosin binds to the actin

3.The power stroke of the cross bridge occurs, which causes the sliding of the thin filaments

4.ATP binds to the cross bridge, resulting in the cross bridge disconnecting from the actin

5.The ATP is hydrolysed, leading to the repositioning of the cross bridge

6.Calcium ions are transported back into the sarcoplasmic reticulum

The diagram above shows a stretched muscle where the I - bands and the H - zone is elongated due to reduced overlapping of the myosin and actin filaments. There would be reduced muscle strength because few cross bridges can form between the actin and myosin.

The diagram above shows a fully contracted muscle with lots of overlap between the actin and myosin. Because the thin actin filaments have overlapped there is a reduced potential for cross bridges to form again.

This is the end of the topic

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Drafted by Eva (Biology)

Photo references:

1. https://teaching.ncl.ac.uk/bms/wiki/index.php/Skeletal_muscle
2. https://training.seer.cancer.gov/anatomy/muscular/structure.html
3. https://en.wikipedia.org/wiki/Sarcomere
4. https://www.pinterest.fr/pin/727190671052241074/
5. https://biology.stackexchange.com/questions/1243/stabbing-muscles-when-flexed-and-when-relaxed
6. https://www.teachpe.com/anatomy-physiology/sliding-filament-theory